What Kinetic Edge offers

Kinetic Edge believes in getting the fundamentals right, the right assays at the right time, with the right analysis, to generate robust decision-making data.

Kinetic Edge offers comprehensive training to build awareness of the role of enzymology in drug discovery and its positive impact. Appreciating what your assay can do, and its limitations, is crucial in building robust data sets.

Kinetic Edge can offer one-off services or work with start-ups to help setup their biochemical processes.

Assay development

Guidance building robust stopped and continuous assays. Their merits and place in the hit discovery cascade. Appropriate technologies and how to bias assays to identify a chosen MoA. Using model and physiologically relevant reagents to mitigate risk in the hit finding cascade.                                

Data analysis

Analysing your data with the correct model is essential to understand your targets/compounds. What does it mean when data deviates from the chosen model? What are the important considerations when analysing your data? Kinetic Edge can offer data analysis or advice. Make your data FAIR and AI ready.

Compound MoA

Biochemical methods to understand the mechanism of action of compounds. From their dependence on substrate or protein partners to measuring on and off rates. The principles are applicable across all modalities; from PROTACs and molecular glues through to covalents.                                                                              

Enzyme MoA

For challenging projects, deeper target characterisation can be transformative. Kinetic Edge can advise on different approaches and their limitations.                                                                                                                                                                                                                     

Kinetic modelling

Often, targets do not conform to the established models, making data analysis challenging. Modelling packages can help rationalise data or fit real data to more complex models where the equations are not easily accessible.                            

Training

Upskill your workforce by equipping them with a deeper understanding of the theory and principles that underpin enzymology and its place in drug discovery. Bespoke packages can be designed encompassing any of the services highlighted here.

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